OBJECTIVES: The aim of this study was to elucidate the molecular features of genes, plasmids and clones of OXA 48 like producingKlebsiella pneumoniae isolates recovered in Sahloul Hospital Sousse, Tunisia in the period 2012 2014. ...CONCLUSION: This study reports the full molecular characterisation of carbapenem resistance in K. pneumoniae and the predominance of a few clones responsible for the dissemination of OXA 48 and OXA 204 enzymes in a Tunisian hospital....