Participants were aged 70 years or older with no history of dementia, cardiovascular disease or physical disability. Interim analysis indicated no significant treatment effect and the trial was terminated slightly early after a median of 4.7 years' follow up. ...One trial 2528 participants investigated the cyclo oxygenase 2 COX 2 inhibitor celecoxib 200 mg twice daily and the non selective NSAID naproxen 220 mg twice daily for preventing dementia in cognitively healthy older adults with a family history of Alzheimer's disease AD . ...