In addition the ESBL gene bla CTX M 15 was detected in 14 K. pneumoniae and 2 E. coli isolates, and the bla CTX M 216 was found in 1 E. coli isolate. ...Conclusion: This study reports the first description of OXA 48 like producing Enterobacteriaceae and NDM 5 enzymes in E. coli in Yemen....