Coronavirus disease 2019 COVID 19 has become a global crisis rapidly since its initial outbreak in Wuhan, China, in December, 2019. ...In this article, we share our local experience in the stroke unit at Aseer Central Hospital which is the main hub of stroke patients in the southwestern part of Saudi Arabia and the primary regional COVID center to provide guidance to perform smooth, safe, and swift mechanical thrombectomy during the coronavirus COVID 19 pandemic as well as possible similar future situations....