Kamlesh Khunti MD, Hungta Chen PhD, Javier Cid Ruzafa MD, Peter Fenici MD, Marilia B. Gomes MD, Niklas Hammar PhD, Linong Ji MD, Mikhail Kosiborod MD, Stuart Pocock MSc, Marina V. Shestakova MD, Iichiro Shimomura MD, Fengming Tang MSc, Hirotaka Watada MD, Antonio Nicolucci MD, on behalf of the DISCOVER investigators