Clinical Review Report: Lixisenatide (Adlyxine): (Sanofi-aventis Canada Inc.): Indication: As an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes mellitus in combination with metformin, a sulfonylurea (alone or with metformin), pioglitazone (alone or with metformin), a basal insulin (alone or with metformin), when the therapy listed above does not provide adequate glycemic control [Internet].