INTRODUCTION: Human papillomavirus HPV vaccination has not been introduced in many countries in South Central Asia, including Afghanistan, despite the sub region having the highest incidence rate of cervical cancer in Asia. ...RESULTS: Vaccinating a single cohort of 9 year old girls against HPV in Afghanistan could avert 1718 cervical cancer cases, 125 hospitalizations, and 1612 deaths over the lifetime of the cohort. ...