It is the primary drug of choice for procedural sedation, preoperative sedation, and in emergency departments. Repeated administration of this drug is reported to have abuse potential and may cause this by increasing dopaminergic neurotransmission. Since an important role of 5 hydroxy tryptamine 5 HT is there in the pathophysiology of anxiety and addiction, administration of midazolam may involve altered 5 HT metabolism as well. ...