Aurora kinases AURKs were identified as promising druggable targets for targeted cancer therapy. Aiming at the development of novel chemotype of dual AURKA B inhibitors, herein we report the design and synthesis of three series of 4 anilinoquinoline derivatives bearing a sulfonamide moiety 5a d, 9a d and 11a d . ...Also, 9d emerged as the most efficient anti proliferative analogue in the US NCI anticancer assay toward the NCI 60 cell lines panel, with broad spectrum activity against different cell lines from diverse cancer subpanels. ...