We found that the need for prophylactic indomethacin OR 1.67 , the occurrence of air leaks OR: 2.35 , ventilator associated pneumonia OR: 2.01 , isolated bowel perforations OR: 3.7 , blood culture proven sepsis OR: 1.5 , other infections OR: 1.44 , and receiving ventricular shunt OR: 2.9 are significantly associated with the development of ROP. ...