Related Articles Molecularly imprinted Spongy Columns for Angiotensin II Recognition from Human Serum Biotechnol Prog 2020 Dec 20 Authors Y ld r m M Pe int GB Abstract Angiotensin II AngII the effector peptide of the renin angiotensin system and has an important role in regulating cardiovascular hemodynamics and structure AngII is an important biomarker for certain diseases that are associated with cardiovascular disorders ie influenza SARS CoV 2 tumors hypertension etc However AngII presents in blood in very low concentrations and they are not stable due to their reactivity therefore spontaneous detection of AngII is a big challenge In this study AngII imprinted spongy columns AngII misc synthesized for AngII detection from human serum and characterized by surface area measurements BET swelling tests scanning electron microscopy SEM FTIR studies AngII binding studies were achieved from aqueous environment and maximum binding capacity was found as 0 667 mg g It was calculated that the AngII miscs recognized AngII 8 27 and 14 25 times more selectively than competitor Angiotensin I and Vasopressin molecules Newly produced AngII misc binds 60 5 pg g AngII from crude human serum selectively It has a great potential for spontaneous detection of AngII from human serum for direct and critical measurements in serious diseases ie heart attacks SARS CoV 2 etc This article is protected by copyright All rights reserved PMID 33342088 PubMed as supplied by publisher