With respect to the main role of amyloid A plaques as one of the pathological hallmarks in the brain of Alzheimer's patients, the development of new imaging probes for targeted detection of A plaques has attracted considerable interests. ...This radiopeptide revealed a good affinity for A 42 aggregations K d 20 M in binding affinity study and this result was confirmed by binding to A plaques in brain sections of human Alzheimer's disease AD and rat models using in vitro autoradiography, fluorescent staining, and planar scintigraphy. ...