Related Articles Acute Kidney Injury and Renal Replacement Therapy in Critically Ill COVID 19 Patients Risk Factors and Outcomes A Single Center Experience in Brazil Blood Purif 2020 Dec 18 1 11 Authors Doher MP Torres de Carvalho FR Scherer PF Matsui TN Ammirati AL Caldin da Silva B Barbeiro BG Carneiro FD Corr a TD Ferraz LJR Dos Santos BFC Pereira VG Batista MC Monte JCM Santos OFP Bellomo R Serpa Neto A Dur o MS Abstract BACKGROUND Critically ill patients with COVID 19 may develop multiple organ dysfunction syndrome including acute kidney injury AKI We report the incidence risk factors associations and outcomes of AKI and renal replacement therapy RRT in critically ill COVID 19 patients METHODS We performed a retrospective cohort study of adult patients with COVID 19 diagnosis admitted to the intensive care unit ICU between March 2020 and May 2020 Multivariable logistic regression analysis was applied to identify risk factors for the development of AKI and use of RRT The primary outcome was 60 day mortality after ICU admission RESULTS 101 50 2 patients developed AKI 72 on the first day of invasive mechanical ventilation IMV and thirty four 17 required RRT Risk factors for AKI included higher baseline Cr OR 2 50 1 33 4 69 p 0 005 diuretic use OR 4 14 1 27 13 49 p 0 019 and IMV OR 7 60 1 37 42 05 p 0 020 A higher C reactive protein level was an additional risk factor for RRT OR 2 12 1 16 4 33 p 0 023 Overall 60 day mortality was 14 4 23 8 n 24 in the AKI group versus 5 n 5 in the non AKI group HR 2 79 1 04 7 49 p 0 040 and 35 3 n 12 in the RRT group versus 10 2 n 17 in the non RRT group respectively HR 2 21 1 01 4 85 p 0 047 CONCLUSIONS AKI was common among critically ill COVID 19 patients and occurred early in association with IMV One in 6 AKI patients received RRT and 1 in 3 patients treated with RRT died in hospital These findings provide important prognostic information for clinicians caring for these patients PMID 33341806 PubMed as supplied by publisher