BACKGROUND: We hypothesized that SKA2 gene can convert hemoglobin F to A leading to the maturity of the hematopoietic system by glucocorticoid hormone so, the present study aimed to investigate the health outcome of newborns by using the effect of SKA2 gene on hematopoietic maturation. ...CONCLUSION: The results revealed that the SKA2 gene affected on hematopoietic maturation in preterm and term newborns and the health outcome of newborns improved by increasing HbA level....