On 3 March 2020 the Ethiopian Public Health Institute EPHI reported three suspected yellow fever cases in Enor Ener Woreda Gurage zone SNNPR The three reported cases were members of the same household father mother and son located in a rural kebele Two of three samples tested positive at national level by reverse transcriptase polymerase chain reaction RT PCR and were subsequently confirmed positive by plaque reduction neutralization testing PRNT at the regional reference laboratory Uganda Viral Research Institute UVRI on 28 March 2020 In response to the positive RT PCR results the EPHI and Ministry of Health performed an in depth investigation and response supported by partners including WHO