These responses are under the control of complex signaling pathways, which are still poorly understood. Here, we show that the rapid activation of clade A Mitogen Activated Protein Kinases MAPKs MPK3 and MPK6 by wounding depends on the upstream MAPK Kinases MAP2Ks MKK4 and MKK5 but is independent of jasmonic acid JA signaling. In addition, this fast module does not control wound triggered JA accumulation in Arabidopsis, unlike its orthologues in tobacco. ...