Related Articles Drug targets for corona virus A systematic review Indian J Pharmacol 2020 Jan Feb 52 1 56 65 Authors Prajapat M Sarma P Shekhar N Avti P Sinha S Kaur H Kumar S Bhattacharyya A Kumar H Bansal S Medhi B Abstract The 2019 novel coronavirus nCoV is a major source of disaster in the 21th century However the lack of specific drugs to prevent treat an attack is a major need at this current point of time In this regard we conducted a systematic review to identify major druggable targets in coronavirus CoV We searched PubMed and RCSB database with keywords HCoV NCoV corona virus SERS CoV MERS CoV 2019 nCoV crystal structure X ray crystallography structure NMR structure target and drug target till Feb 3 2020 The search identified seven major targets spike protein envelop protein membrane protein protease nucleocapsid protein hemagglutinin esterase and helicase for which drug design can be considered There are other 16 nonstructural proteins NSPs which can also be considered from the drug design perspective The major structural proteins and NSPs may serve an important role from drug design perspectives However the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV specific vaccines drugs PMID 32201449 PubMed indexed for MEDLINE