Related Articles Hyperinflammation and Immune Response Generation in COVID 19 Neuroimmunomodulation 2020 Dec 18 1 7 Authors Mishra KP Singh AK Singh SB Abstract Severe acute respiratory syndrome coronavirus 2 SARS CoV 2 that causes coronavirus disease 2019 COVID 19 pandemic has affected millions of people worldwide The pathophysiology of this virus is not very clearly known thus enormous efforts are being made by the scientific community to delineate its evading mechanism In this review we have summarized the hyperinflammation and humoral and cell mediated immune response generated in human body after infection with the SARS CoV 2 virus The inflammatory response generated after infection by increased proinflammatory cytokines and chemokines and complement proteins activation may likely contribute to disease severity We also discussed the other factors that may affect immunity and could be important comorbidities in the disease severity and outcome PMID 33341814 PubMed as supplied by publisher