BACKGROUND: Cancer contributes to significant morbidity and mortality despite advances in treatment and supportive care. There is a need for identification of effective anticancer agents. ...Such species are rarely reported to develop cancer, suggesting presence of anticancer molecules mechanisms. METHODS: Here, we tested effects from sera of Asian water monitor lizard Varanus salvator , python Malayopython reticulatus and tortoise Cuora kamaroma amboinensis against cancer cells. ...