Multidrug resistant tuberculosis MDR TB is becoming a global health crisis. The World Health Organization has released new guidelines for the use of tuberculosis active drugs for the treatment of patients with MDR TB. Despite documented activity against tuberculosis isolates, doses and exposure targets are yet to be optimized. Our objective was therefore to review the clinical pharmacokinetic and pharmacodynamic literature pertaining to drugs recommended to treat MDR TB and to identify target areas for future research. ...