Brain secretase tubulin binding protein and tau proteins which are responsible for the synthesis of amyloid protein that may interfere with neuronal communication in Alzheimer's disease AD were also upregulated regarding hepatic function, AlCl 3 elevated serum alanine aminotransferase ALT and aspartate aminotransferase AST activities. ...So, we hypothesize that acute AlCl 3 administration is responsible for oxidative cell damage that interferes with brain function inducing amyloid accumulation, Alzheimer's disease, and neurodegenerative damage as well as hepatorenal injuries....