Caregivers were assessed with the medical outcome survey short form SF 36 , the Zarit Burden Interview ZBI and the Depression Anxiety and Stress scales DASS 21 .Results: Caregivers' mental quality of life was impaired with an average mental score of 59.05. ...After controlling for demographic variables age and gender and patients' health related variables level of dependency, comorbidities, age onset of illness, number of hospitalizations and duration of clinical remission , caregivers' levels of depression, stress, and SF 36 physical component significantly contributed to their perceived burden.Conclusions: Certain modifiable risk factors play an inescapable role in increasing the level of burden among caregivers of older patients with serious mental illnesses.Clinical Implications: Improving the quality of life and psychological well being of family caregivers should be considered an integral part of treatment for serious mental illness in older adult patients....