Liver cancer LC is the worldwide disease and currently, due to the poor prognostic and therapeutic options of liver cancer, we investigated the T cell epitopes as potential therapeutic vaccine candidates to get the benefit of experimental processes and utilize the complete ability of the immune system compared to other artificial ex vivo proliferation of T cells. ...We found the binding affinity of antigenic peptides with MHC I molecules to control the cancerous activity. Five extracellular antigenic proteins including complement protein C6 , serotransferrin TF , coagulation factor XIII B F13B , serum albumin ALB , and prothrombin F2 were identified. ...