Increasing antibiotic resistance in multidrug resistant MDR Gram negative bacteria MDR GNB presents significant health problems worldwide, since the vital available and effective antibiotics, including broad spectrum penicillins, fluoroquinolones, aminoglycosides, and lactams, such as carbapenems, monobactam, and cephalosporins often fail to fight MDR Gram negative pathogens as well as the absence of new antibiotics that can defeat these 'superbugs'. ...