Ryoichi Sadahiro MD, PhD, Norie Sawada MD, PhD, Yutaka J. Matsuoka MD, PhD, Masaru Mimura MD, PhD, Shoko Nozaki MD, PhD, Ryo Shikimoto MD, PhD, Atsushi Goto MD, PhD, Shoichiro Tsugane MD, PhD, for the Japan Public Health Center Based Prospective Study Group