On 30 September 2020 the French Guiana Regional Health Agency ARS reported the first detection of Oropouche virus OROV in French Guiana On 22 September 2020 the Pasteur Institute in Cayenne a member of the French National Reference Laboratory for arboviruses notified the France IHR National Focal Point of seven laboratory confirmed cases of Oropouche virus infection in the village of Sa l These cases were identified following clinical investigations of an unusually high number of dengue like illnesses in the village Between 11 August and 25 September there were 37 clinically compatible cases of Oropouche virus disease identified in Sa l The results of serology for dengue chikungunya and Zika were negative and seven of nine cases tested positive for OROV by reverse transcriptase polymerase chain reaction RT PCR Among the 37 clinically compatible cases most cases are male 60 and the median age is 36 years range 3 82 years The most represented age range is 15 to 54 years old 19 cases followed by 0 to 14 years old 10 cases A peak of cases was observed in mid September however the outbreak investigation remains ongoing